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 Formulary Chapter 2: Cardiovascular system - Full Chapter
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02.05.05.03  Expand sub section  Renin inhibitors
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 Non Formulary Items
Aliskiren

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Non Formulary
Black

 

  • Not included in NICE hypertension guideline as insufficient evidence of its effectiveness.
  • See also safety concerns (see links below).
  • Prescribers in Primary Care should not initiate aliskiren for any new patient.

  • Patients currently prescribed aliskiren should be reviewed by their specialist/initiating trust and aliskiren deprescribed.

  • CUHFT have withdrawn their current shared care guideline.

     

 

 

Link  EMA advise clinicians to review Aliskiren prescribing following termination of ALTITUDE study
Link  MHRA: Aliskiren (Rasilez): risk of angioedema and renal dysfunction
Link  MHRA: Aliskiren (Rasilez): risk of cardiovascular and renal adverse reactions—new contraindications and warnings
 
Rasitro®
(Aliskeren / amlodipine / hydrochlorothiazide )

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Non Formulary
Grey
Link  MHRA Drug Safety Update: Hydrochlorothiazide- risk of non-melanoma skin cancer, particularly in long-term use
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
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Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

OTC

Available Over the Counter. Consider Self Care   

Green

Formulary - Can be prescribed in both secondary and primary care.   

Advice

Formulary - Specialist Advice, secondary care advice provided for primary care initiation.  

Amber No SCG

Formulary - Specialist initiation without shared care guidance.  

Amber SCG

Formulary - Specialist initiation with shared care guidance.  

Red Hospital

Restricted - Hospital only, not to be prescribed in primary care.  

Switch

Not recommended for prescribing. Switch to alternative cost-effective option.   

Black

Not recommended for prescribing in primary or secondary care.  

Grey

Not recommended as no formal application made for addition to the formulary. Contact relevant pharmacy team for further information.   

Non Formulary

Non-Formulary (category under review).  

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